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While reducing particle size can improve tissue permeability, it may also compromise stability, necessitating careful selection of an appropriate particle size to optimize the delivery effect of each DDS ( Long-circulating drug carriers are particularly advantageous in DDS, as prolonged circulation can increase drug accumulation at the target site, while overly rapid clearance may prevent drugs from achieving their full therapeutic potential (Ou et al., 2018)

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[DOI] [PubMed] [Google Scholar] 81.Suárez-Cuenca J.A., Ruíz-Hernández A.S., Mendoza-Castañeda A.A., Domínguez-Pérez G.A., Hernández-Patricio A., Vera-Gómez E., De La Peña-Sosa G., Banderas-Lares D.Z., Montoya-Ramírez J., Blas-Azotla R., et al