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88 In recent years, studies have revealed that UA activates the TLR4-NLRP3 inflammatory complex, which is a multi-protein complex that plays a pivotal role in initiating the innate immune response to various danger signals, including MSU crystals
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While the somatic mutations seen in cancer do not occur in the mood disorders, changes in gene expression driven by epigenetic mechanisms convey losses in neuroprotective factors (the “good guys”) and increases chemical alterations driving behavioral pathology (the “bad guys”)
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