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As compared to dieting alone (e.g., dieting by caloric restriction, low-carbohydrate diet, ketogenic diet, vegan diet, etc.), where weight loss occurs in both fat stores and muscle during dieting, administration of a myostatin inhibitor disclosed herein (e.g., an anti-myostatin antibody or antigenbinding fragment thereof disclosed herein, e.g., Ab102, Ab109, Ab130, Ab132, Ab133, or Ab141 ) leads to weight loss in fat stores, while sparing the muscle

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Wang T, Feldman GM, Herlyn M, Kaufman RE