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The group of Pei showed that desensitization of KOR-mediated extracellular acidification response was greater upon dynorphin A (1-13) stimulation than U69,593 ((+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide) and etorphine (Ling et al., 1998)
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Strength:3000 mcg/mL
This goal could be achieved by engineering the involved metabolic pathways through genetic improvement by targeting some specific genes encoding enzymes (Liu Y
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