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In HNC, where oxidative stress is inherently elevated due to metabolic reprogramming and therapy-induced ROS, Nrf2-mediated reinforcement of ferroptosis resistance provides a critical advantage for tumor progression and therapy evasion [41,51]
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Four phenazines (pyocyanin, phenazine-carboxamide, phenazine-carboxylic acid, and 1-hydroxy-phenazine) are produced by P
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