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In EAE, TNFR1(p55) is supposed to be responsible for the detrimental effects of TNF-Ξ± by initiating and exacerbating the course of disease while immunosuppressive and immunoregulatory properties of TNF-Ξ± are thought to be mediated by action through TNFR2(p75) (Eugster et al., 1999
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