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The grids were loaded onto a 300 keV Titan Krios (FEI) with a K3 direct electron detector (Gatan) and an energy filter

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FIGURE 1 FIGURE 2 It is important to note that although we have found the multi-target effects of quercetin in the treatment of acne vulgaris, the interrelationships and synergistic mechanisms among these targets remain incompletely elucidated