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The expression of HIF-1ฮฑ mRNA and BAX mRNA was significantly higher in patients with active CD compared with controls and patients on GFD, while no difference was observed between the latter two groups
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In the cytoplasm, vitamin B12 deficiency impacts the enzyme methionine synthase, with some consequences that adversely affect DNA, RNA, proteins, neurotransmitters, and phospholipids, and with some consequences that indirectly contribute to oxidative stress
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