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argued that a number of elderly without neurological disease are found to have extensive synucleinopathy ranging up to Braak stages 4 to 6.[43] In addition, they add, there is no correlation between the Braak stage and the clinical severity of the disease—that is, there is no correlation with a measure of the density and extensive presence of Lewy bodies throughout the CNS

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They must not be used for clinical, diagnostic, or therapeutic applications