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Misdiagnoses, and the variability in symptom severity within ME/CFS cohorts, likely influences study outcomes aimed at identification of disease-associated biomarkers (Xu et al., 2023)

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Chronic Insomnia: In an open-label study involving patients with severe chronic insomnia, a treatment regimen of 10 intravenous injections of DSIP (25 nmol/kg) resulted in a normalization of sleep patterns that persisted for follow-up periods of 3 to 7 months.Crucially, the patients reported not just improved sleep duration, but improved daytime mood and performance, distinguishing DSIP from benzodiazepines which often cause daytime drowsiness and cognitive impairment

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