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Therefore, it is reasonable to assume that the chronic hepatotoxicity of AX would be similar in quality and level to that of other carotenoids ingested in large daily doses and that it is probably safe at the doses used in the clinical trials
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The E3 ligase c-Cbl is frequently dysregulated in myelodysplastic-myeloproliferative neoplasms and is also couped with myelodysplastic syndromes, myeloid neoplasms, and primary colorectal cancer [1]
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