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Consistent with this, pharmacological inhibition of coagulation by heparin and genetic approaches (mice deficient in either tissue factor or PAR-1) attenuate APAP hepatotoxicity at an early stage (6 h) [33]
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Others reported that miR-34a was upregulated in MCD-fed mice, and following treatment with metformin, this effect attenuated miRNA expression (42)
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