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The 70% of glaucoma cases are caused by elevated IOP, but it is clear that different molecular mechanisms are involved, such as oxidative stress, glutamate toxicity, neurotrophin deprivation, mitochondrial dysfunction, ischemia/hypoxia processes, protein misfolding, autoimmunity, dysfunction of autophagy processes, vascular dysregulation or neuroinflammation, which may also be responsible for RGC degeneration and death in cases of non-elevated IOP (Chang and Goldberg, 2012