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In an earlier Phase 2 study, CagriSema produced significantly greater weight loss than semaglutide or cagrilintide alone, and was generally well tolerated
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Thus, TB-500 may be hypothesized to support angiogenesis by combining a cytoskeleton-linked increase in endothelial motility with signaling changes that raise pro-angiogenic programs (VEGF-A and Ang2/Tie2) via Notch/NF-κB coupling in damaged cellular structure
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