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Nevertheless, a modification of the Haber-Weiss reaction, the Fenton reaction and Fenton-like reactions, utilizes the redox cycling ability of iron to increase the rate of reaction, is more feasible (Chance et al., 1979
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26,43,44 The enzymes UGT (glucouronidation), SULT, CYP 450, GST, N -deacetylase (deacetylation), NAT2 (deacetylation), and fatty acid amide hydrolase are involved in APAP metabolism and have been shown to be related to both hepatic and nephrotoxic effects of the analgesic medication
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