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The depletion of GSH has been directly linked to an increase in pathogenicity of infection (Ristoff et al., 2001
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Triptolide reduced TGF-β1-induced overexpression of LOX, LOXL1, and LOXL2, as well as total LOX activity, diminishing oxidative stress and altering endopeptidase expression such as MMP2, MMP9, MMP13, and MMP14
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