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According to research, smoking accounts for over 70% of COPD cases in high-income countries, whereas in low- and middle-income countries, this proportion ranges from 30% to 40% ( Beyond active smoking, other risk factors for COPD also encompass passive smoking, environmental and occupational exposures, infectious factors, an unhealthy diet, and individual factors (such as gender and age differences, as well as genetic factors) ( Figure 1

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doi:10.1038/ejcn.2014.281