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However, the metabolism of arginine by one pathway often suppresses the other

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Oral administration After oral administration, no heroin or 6-MAM can be detected in the blood (because of hydrolysis in the duodenum and colon, and virtually complete hepatic first-pass effect), whereas circulating morphine reaches significant levels (about 80% of that measured after the administration of an equal dose of morphine, but with shorter T max ) [23, 47]