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Table of Contents Clinical Shift to Pediatric Histiocytosis Regimens Efficacy in Resistant and First-Line Cases Chronic Manifestations and Discontinuation Hurdles Closing Thoughts Clinical Shift to Pediatric Histiocytosis Regimens Langerhans cell histiocytosis, the most common histiocytic disorder in children, is a rare blood-cell cancer in which immune cells called Langerhans cells accumulate and damage tissue in the bone, skin, liver, spleen, or brain
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