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Detecting the collided ribosomes The “canonical” RQC mechanism is initiated by ZNF598, an RNA‐binding and E3 ubiquitin ligase protein that detects the collided ribosomes and promotes the preferential ubiquitination of the eS10 (RPS10), eS3, and eS20 ribosomal subunits by the E2 ubiquitin ligase UBE2D3 [16, 20]
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