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This intricate nexus, predominantly involving peripherally activated immune cells, notably circulating monocytes, and microglia, along with its repercussions on signaling pathways like serotonin, dopamine, and corticotropin-releasing hormone, with the latterโs implications on the hypothalamus-pituitaryโadrenal axis, initiates sickness behaviors, including fatigue (4, 8)
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TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death
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