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Then, we are dealing with a perturbation of the equilibrium between two enzymes working in opposition, i.e., NOX, requiring NADPH to produce O 2 −• , and GR, using NADPH to restore GSH levels, with NADPH being probably channelled preferentially towards NOX rather than GR reaction
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For example, p53 activation regulates the expression of a variety of genes to protect NDD-associated neurons from DNA damage
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