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Both the shapes and sizes of nanoparticles can influence how neuronal cells regenerate themselves, becoming either differentiated or undifferentiated culminating in life-or-death issues bringing the focus to nanoscaffolds, nanotubes, and nanowires ( Some nanoparticles have been designed to target neurons more specifically, such as gold NPs coated with exosomes that carry Rabies Virus Glycoprotein (RVG) peptide and lysosome-associated membrane protein 2b (RVG-Lamp2b) fusion peptides ( in vitro ( in vivo targeting of specific neuronal subtypes, including dopaminergic, glutamatergic, and GABAergic neurons, highlighting the need to develop this approach for receptors that exhibit dynamic expression in NDs