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Tirzepatide instead engineers a single peptide to activate two incretin receptors (GIP and GLP-1) at once

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In contrast to acyl-CoAs, which remain sequestered in mitochondria, ACs can be transported out of mitochondria and out of the cell to the blood-stream and thereby directly reflect the intracellular pool of corresponding acyl-CoAs( Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that regulates transcription by binding to the PPARα response elements of several genes, including genes related to mitochondrial and peroxisomal β-FAO ( In this study, we propose to investigate the possible mechanism of VPA-induced disorder of ACs profiles, relative gene expression, including ACs transport and β-FAO enzyme was tested at the cellular and animal levels to explore the candidate biomarkers for VPA-induced abnormal liver function