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Other hallmarks of the final stages of oocyte maturation are cortical granule redistribution and cumulus cell expansion [53], [54], [55] In vitro studies have shown that melatonin significantly increase the expansion of cumulus cells in sheep [56], pig [57] and mice [58], observations that are confirmed in vivo [59]

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This indicates an interesting GSH-dependent threshold regulation that is important for the subset-specific functions of B cells and a differential redox-dependent regulation of metabolic activities in these cells