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Because MT-II has a cumulative effect on melanin density, research protocols typically transition from a daily “loading phase” to a vastly reduced “maintenance schedule” (e.g., 1 to 2 times weekly) once the target melanogenic baseline is achieved.¹ Route of Administration The standard route of administration in clinical literature is Subcutaneous (SubQ) injection

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When researchers spaced out doses, the biological effect weakened even though the same total exposure occurred over time