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JAK2V617F constitutively activates the PI3K/AKT/mTOR cascade alongside STAT5, and JAK2 inhibition alone often fails to fully suppress mTORC1, allowing neoplastic cells to escape apoptosis (91)
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ADHD is also influenced by neurodevelopmental exposure to pregnancy and delivery complications, lead, pesticides, polychlorinated biphenyls, and other toxins (Banerjee, Middleton, & Faraone, 2007)
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