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Others Oxidative stress Currently, the detection of oxidative stress and reduced antioxidant defenses has been found in both in the AN chewer and OSF patients

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For instance, in a six-month randomized controlled trial of 72 patients with Friedreich’s ataxia (a neurodegenerative disorder characterized by mitochondrial iron accumulation), 20 mg/kg/day DFP was well tolerated but higher doses (40 and 60 mg/kg/day) were associated with increased adverse events and worsening of ataxia symptoms (Pandolfo et al., 2014)