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Urate and Uric Acid have Moderate Neuroprotective Properties Uric acid (UA) is a natural antioxidant that can reduce oxidative stress by acting as a scavenger of free radicals and an iron chealator (Ames et al., 1998
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Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNFα killing by inducing IKK-β-SSG formation, leading to suppressed NF-κB activation
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