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HepG2 human hepatoma cells treated with curcumin (between concentrations of 1 µM and 50 µM) showed a dose-dependent increase in CYP3A4 transcription (45)
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Previous work between cross-national collaborators to develop a template data use agreement for access to ‘factually anonymous’ data via remote access to a safe room, provides an example of how the framework can be adapted to suit national, legal, institutional and technical requirements [15]
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