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147 , rapamycin, an mTOR inhibitor, effectively mitigated IL-1β-induced chondrocyte apoptosis and inflammation via upregulation of LC3B, downregulation of apoptotic markers including cleaved-caspase-3, and activation of PI3K/Akt signaling pathway
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However, this stressor must be present in moderation, otherwise the cell fails to adapt, and oxidative stress rises as an indicator of this maladaptation to low energy availability (32)
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