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However, when the metabolic balance is overwhelmed and the sum of free radicals in a cell is greater than the capacity of the cell to detoxify these substances, oxidative stress is generated
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A small number of GHR antagonists have been used in an oncology settings in preclinical studies and the growth-inhibiting effects have been reported in colon, breast, and meningioma tumor xenografts, which suggested that GHR antagonism as a monotherapy is efficient in some tumor types (Friend, 2001
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