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It would later prove that their neurotoxicity involve iron-mediated oxidative stress (reviewed: Blum et al
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What’s more, the NOD-like receptor family pyrin domain-containing 3 (NLRP3), also upregulated by the activation of NF-κB, 38 forms inflammasome and activates protein kinase C epsilon (PKCε), 39 thus imparting IRS-1 40 (Fig
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