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The in vitro photosensitising ability of 16a and 16b was investigated by incubation both with KB human nasopharyngeal carcinoma cells, which have high expression of FRα and with MCF-7 human breast adenocarcinoma cells, which have low expression of FRα.50 No cytotoxic activity was detected for either in the absence of light, whereas activity was observed upon the illumination with IR light
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There are no standardized dosing guidelines , and no approved clinical safety or efficacy data for human use
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