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The percentage of the anorexigenic effect on the experimental day was calculated by subtracting the observed to the basal intake and then dividing the result by observed intake, by the following formula [29–31]: Dose-response curves were constructed by plotting the % of anorexigenic effect against the tesofensine or 5-HCP/CB administered individually, and ED30 (+ SEM) values were estimated by linear regression
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