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Vitamin B12 deficiency during development is associated with delay in the development of speech Vitamin B12 deficiency results in reduced methylation of Myelin Basic Protein, and resultant disruption of the myelin sheath Inadequate myelination in the various regions of the brain is common in children with autism Altered MBP results in the production of anti-BMP antibodies Vitamin B12 deficiency reduces the production of melatonin in the child and is associated with sleep disorders in ASD Vitamin B12 deficiency reduces the production of gut melatonin and is associated with poor intestinal health, lactose intolerance and multiple food intolerance

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Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis