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Patients with cerebral edema have a high incidence of seizures, but prophylactic antiseizure medications such as phenytoin have not been proven to be beneficial
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The present – hallmarks of the modern cuprizone model To standardize the cuprizone model, Hiremath and colleagues introduced a protocol for lower-dose cuprizone administration (0.2% w/w) in C57BL/6 mice in 1998 [42, 43] that is still widely used today
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