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Structural modifications allow them to stay in circulation for hours or even days: IGF-1 LR3 : 20–30 hour half-life CJC-1295 with DAC : 5–8 day half-life PEG-MGF : detectable for up to 1–2 weeks “Pharmacokinetic enhancements such as PEGylation or fatty acid acylation extend the peptide’s residence time, reduce renal clearance, and improve therapeutic utility.” — Veronese & Mero, BioDrugs What Determines How Long Peptides Stay in Your System

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