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Proteins are likely to be major targets, as a result of their abundance in cells (proteins compose approximately 70% of the dry mass of most cells), plasma, and most tissues, and their rapid rates of reaction both with many radicals and with other oxidants.48 Proteins are one of the major categories of age-related damage in macromolecules, which have been observed during various cells, tissues and organs.1 ROS can lead to oxidation of amino acid residue side chains, formation of protein-protein cross-linkages, and oxidation of the protein backbone resulting in protein fragmentation.49 One of the greatest challenges in aging research today is the identification of specific cause of oxidative modification and accumulation of macromolecules specifically proteins

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Cysteine is described in nutritional literature as conditionally essential — meaning it is not strictly essential (the body can produce it from methionine, another sulphur-containing amino acid) but the production pathway has limits, and dietary cysteine remains relevant