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Discussion Patients with stable schizophrenia had lower levels of glutathione and glutamate in the ACC, as measured by component scores representing variance shared between glutathione and glutamate in the ACC
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In summary, the reactivity of glutathione (GSH) is a crucial consideration for covalent drug development, leading to a growing focus on designing lower-reactivity warheads to minimize non-specific covalent binding and reduce the risk of adverse reactions
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