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Further highlighting the functional relationship between Ec CnoX and GroEL/ES, GroEL/ES obligate substrates are over-represented in the proteins found in a mixed-disulfide complex with Ec CnoX ( Our Working Model By joining the pieces of the Ec CnoX puzzle, we came to the following model (Figure 2)
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Chronic stress is considered a key precipitating factor in central nervous system dysfunction in ME/CFS and may impair brain structure and function through multiple mechanisms
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