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10.1371/journal.pone.0108210 41 TirmensteinM
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In the same subset of cells, the cyclin-dependent kinase inhibitor p27 (p27 kip1 , a molecule involved in the control of cell cycle and T cell anergy) was elevated before and after anti-CD3/28 stimulation, and leptin neutralization induced degradation of this molecule, partly explaining the reversal of the anergic state and proliferation of these cells
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