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The standard care for tendon, ligament, muscle, and bone injuries remains the foundation, and it’s a foundation built on decades of solid evidence: Conservative treatment : Rest, physical therapy, progressive loading, anti-inflammatory management, and activity modification remain first-line approaches for most musculoskeletal injuries

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Most work agrees that NO signaling in the brain promotes both baseline sleep, and increased homeostatic rebound sleep after acute sleep deprivation (Gautier-Sauvigné et al., 2005

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