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However, in aldehyde dehydrogenase 2 knockout (ALDH2 −/− ) mice (ALDH2—an enzyme critical for protecting the heart against oxidative damage), no cardioprotective effects of ALA were observed
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This selective mechanism has made it a focus of research in obesity, fat metabolism, and cartilage repair, offering a more targeted metabolic profile without the systemic hormonal effects associated with growth hormone.
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