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As GLP-1R-targeted nanomedicines advance toward clinical application, an in-depth understanding of nanomaterial–immune system interactions, long-term retention effects, and rigorous toxicological validation will be essential for ensuring safety, regulatory approval, and patient benefit in metabolic, cardiovascular, and neurodegenerative disease settings

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Although the mechanisms are not yet clear, they may involve mitochondrial energy metabolism, DNA damage repair, and so on