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The protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/REF-1) negatively regulates Nrf2 through its redox activity, with inhibition of APE1/REF-1 causing significant increases in the levels of Nrf2 and selected target genes HMOX1, GCLC , and GCLM in pancreatic cancer cell lines without causing the generation of ROS [323]
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This highlights that disruptions in these pathways can significantly contribute to the development of ASD
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