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These metabolites were enriched in tricarboxylic acid (TCA) cycle (succinate, citrate, malate), pyrimidine metabolism (CTP, UTP, CDP), purine metabolism (AMP, IMP, GMP), as well as one-carbon (1 C) pool by folate (SAM and SAH) components (Supplementary Fig
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Both are expected to move to Category 1 under the RFK reclassification, potentially mid-2026, which would open a legal compounding route with a physician's prescription
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