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Therefore, we used a hybrid approach in this study to compensate for the shortcomings of each method ( In general, the dynamic behavior of a metabolic pathway is modeled by the following differential equation.where x is the variable vector representing metabolite concentrations (n × 1), S is the stoichiometry matrix (n × m), and v is the reaction rate vector (m × 1), which is a function of x

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Bradford et al., 2011)

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