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Another mechanism induced by damaged neurons that leads to glial cell activation is the release of HMGB proteins, which will bind to CD11b receptors present on glial cells, stimulating the release of inflammatory cytokines and promoting the acquisition of reactive phenotypes (Nakazawa et al., 2006b)

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If your diet is low on foods that contain vitamin B12 or your body cannot appropriately digest those foods, a healthcare professional may recommend that you take an oral supplement each day