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Its action is characterized in vivo by a combination of its own inhibitory effects at the SERT (Dissociation constant [Ki] =0.9 nM) 141 and the SERT-inhibitory effects of its long-acting metabolite norfluoxetine (Ki =2.3 nM), 141 and thus fluoxetine is thought to bring about its antidepressant actions by elevating extracellular 5-HT concentrations
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2016;6 doi: 10.1038/srep30051
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